Teen Young Adult

Age-related Macular Degeneration by L. Ho, R. van Leeuwen, P. T. V. M. de Jong, J. R.

By L. Ho, R. van Leeuwen, P. T. V. M. de Jong, J. R. Vingerling, C. C. W. Klaver (auth.), Frank G. Holz, Daniel Pauleikhoff, Richard F. Spaide, Alan C. Bird (eds.)

Age-related macular degeneration is the most typical reason for the lack of imperative imaginative and prescient past the age of fifty in business countries. Triplication of the variety of affected sufferers is anticipated over the subsequent 25 years. particularly over the past years the normal of information concerning etiology, possibility elements, diagnostics and treatment of this retina ailment has considerably grown – it will be coated during this updated multi-authored paintings. except epidemiologically and genetically pointed out chance components either a few of the pathophysiological facets together with the function of the supplement method and scientific manifestations together with OCT and angiographic features are sincerely represented. in addition, the several healing techniques are offered and mentioned, together with confirmed techniques akin to intravitreal anti-VEGF remedy and seeing-aid structures, as well as the newest and upcoming tools within the sector of pharmacology. the quantity is well-illustrated and tables and summaries entire the presentation.

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Zareparsi S, Branham KE, Li M et al (2005) Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degeneration. Am J Hum Genet 77(1):149–153 64. Hageman GS, Anderson DH, Johnson LV et al (2005) A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci USA 102(20): 7227–7232 65. Sepp T, Khan JC, Thurlby DA et al (2006) Complement factor H variant Y402H is a major risk determinant for geographic atrophy and choroidal neovascularization in smokers and nonsmokers.

Cauc. , Afr. Utheim et al. 5 2 Fig. 99). 87). 51). This suggests that in addition to the known functional polymorphisms rs429358 and rs7412 (that define the e-alleles), cis-regulatory variants of the APOE gene may also influence AMD risk. To date, allele- and genotype-based association tests showed a protective effect of up to 40% for e4 and a causative effect of up to 20% for e2 [180, 183–197]. 00) [74]. 74; Fig. 9a). 35; Fig. 9b). 83; Fig. 28; Fig. 9d). The retina has high levels of oxygen, polyunsaturated fatty acids, and light exposure, which may cause oxidative damage and inflammation [198].

Am J Hum Genet 77(1):149–153 64. Hageman GS, Anderson DH, Johnson LV et al (2005) A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci USA 102(20): 7227–7232 65. Sepp T, Khan JC, Thurlby DA et al (2006) Complement factor H variant Y402H is a major risk determinant for geographic atrophy and choroidal neovascularization in smokers and nonsmokers. Invest Ophthalmol Vis Sci 47(2): 536–540 66. Despriet DD, Klaver CC, Witteman JC et al (2006) Complement factor H polymorphism, complement activators, and risk of age-related macular degeneration.

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