Biotechnology

Bioreactor Systems for Tissue Engineering by D. Wendt, S. A. Riboldi, M. Cioffi, I. Martin (auth.), Dr.

By D. Wendt, S. A. Riboldi, M. Cioffi, I. Martin (auth.), Dr. Cornelia Kasper, Prof. Martijn van Griensven, Dr. Ralf Pörtner (eds.)

The editors of this exact quantity could first wish to thank all authors for his or her very good contributions. we'd additionally prefer to thank Prof. Dr. Thomas Scheper, Dr. Marion Hertel and Ulrike Kreusel for offering the chance to compose this quantity and Springer for organizational and technical aid. Tissue engineering represents one of many significant rising fields in smooth b- expertise; it combines varied topics starting from organic and fabric sciences to engineering and scientific disciplines. the purpose of tissue engineering is the advance of healing techniques to alternative diseased organs or tissues or increase their functionality. as a result, 3 dimensional biocompatible fabrics are seeded with cells and cultivated in appropriate structures to generate sensible tissues. many various elements play a job within the formation of 3D tissue buildings. within the first position the resource of the used cells is of the maximum value. to avoid tissue rejection or immune reaction, preferentially autologous cells are actually used. particularly, stem cells from assorted resources are gaining unprecedented significance as they are often differentiated into diversified tissues by utilizing targeted media and supplementations. within the box of biomaterials, various scaffold fabrics exist already yet new composites also are being constructed in keeping with polymeric, typical or xenogenic resources. furthermore, an important factor in tissue en- neering is the formation of tissues less than good outlined, managed and reprod- ible stipulations. for that reason, a considerable variety of new bioreactors were developed.

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Extra resources for Bioreactor Systems for Tissue Engineering

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In the bioreactor (Fig. 3), the tissue has separate connections: an arterial supply provides it with fresh nutrient solution and through a venous connection the exhausted solution and metabolites are removed. The dynamic in vitro system was designed to provide medium flow by a roller pump (500 ml min-1) in the same way as the heart pumps blood through the human circulatory system in pulses; in the bioreactor the pulse is adjusted in a range from 80 to 200 ± 30 mmHg, with a variable stroke volume of 0–10 ml per stroke and a pulse rate of 60 to 180 beats min-1.

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